- ACR Criteria for Diagnosis of SLE.

American college of Rheumatology (ACR) Criteria

for Diagnosis of Systemic Lupus Erythematosus.

"Sharp Domain"

1. Serositis:Pleuritis, pericarditis.
2. Hematologic disorder (hemolytic anemia OR Leukopenia less than 4,000 OR Lymphopenia less than 1500 or thrombocytopenia less than 100,000).
3. Arthritis:-(nonerosive, involving 2 or more joints).
4. Renal disorder:-(persistent proteinuria > 0.5 grams per day OR cellular CASTS).
5. Photosensitivity:- Rash on exposure to sun light.
   
   

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- Skin manifestations of Systemic Lupus Erythematosus.

Skin manifestations of Systemic Lupus Erythematosus.

"Dr Palm"

• Discoid rash.
• Raynaud's phenomenon: observed at distal digital tips.

• Photosensitivity, Purpuric lesion, Pre-ungual erythema.
• Alopecia:commonly affect the temporal regions.
• Lichen plannus like, Livedo reticularis, leucoderma.
• Malar rash.

Dr Ibrahim

-Sj�gren's syndrome.

Sj�gren's syndrome

(Sicca syndrome.)

*Def:-

It is chronic inflammatory autoimmune disorder in which immune cells attack and destroy the exocrine glands(1)that produce tears and saliva.

*synonymes:-

• Mikulicz disease.
• Sicca syndrome.

*It is named after Swedish ophthalmologist Henrik Sj�gren(2)(1899�1986) who first described it.

*Pathology:-

It is characterized by unusual infiltration of these glands that are responsible for fluid production by lymphocytes, thus causing decreased saliva (dry mouth), decreased tear production (dry eyes), and drying of other mucous membranes.
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