Variants(Types)of Scleroderma.
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A)Systemic sclerosis without Scleroderma:-i.e internal organ involvement without cutaneous scleroderma.B)Overlap syndrome:-scleroderma associated with other autoimmune disease.C)localized scleroderma:-scleroderma without internal organ involvement.Charachterized by Morphoea which are local patches of scleroderma.D)Limited scleroderma(CREST Syndrome):-There is minimal visceral involvement, positive anticentromere antibodies and good prognosis.Skin hardening is limited to face,feet and fingers.(Calcinosis,Raynaud's phenomenon,Esophageal dysfunction,Sclerodactly,Telangectasia.)E)Diffuse scleroderma:-Diffuse thickening of trunk,proximal and distal limbs with internal organ development and damage so it is life threatening. Dr Ibrahim